Antibacterial peptides (AMPs) are one of the most common components of innate immunity The skin of salientia (frogs and toads) is rich in AMPs such as:
What are AMP antibacterial peptides? Why are you studying with frogs?
Antimicrobial peptides (AMPs) are a special class of biologically active peptides [4,5,6,7,8,9,10,11,12]. They are important for their antibacterial effect against various pathogens such as drug resistant bacteria, fungi, viruses and parasites. Bombinin is one of the earliest amphibian peptides [12] .7. 2020
Where are the antibacterial peptides?
Antibacterial peptides are mainly synthesized in insect fat bodies and blood cells. This is one of the main reasons for the strong adaptability of insects to survival (Vilcinskas, 2013). Cecropins are the most famous family of insect-derived AMPs found in silk moths, honeybees and Drosophila.
What is the mechanism of action of antibacterial peptides?
In general, antibacterial peptides kill bacteria by breaking the membrane or entering bacterial cells and interacting with intracellular components.
How do antibacterial peptides kill microbial pathogens?
These peptides penetrate the bacterial membrane, accumulate inside the bacterium, block the function of the bacterium, and induce cell death by interacting with intracellular DNA and RNA. The antibacterial function of these cationic AMPs is primarily to target DNA and induce DNA damage.
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